I got two normal harddisks (c: and d:). I am working on c: and have basically everything there. The d disk is some data and there is the pagefile on d: in case this matters. No SSD yet.
I got windows storage spaces, but compiler, Qt stuff and source are on c:.
I got veraCrypt with one drive letter and a couple network mappings, if they are qualifying as windows storage spaces at all. But this is been in use for some time without problems. Also all activity is directly on c: without such mappings.