[quote author="ronM71" date="1315349947"]So, the "Clear system Environment" in Qt-Creator, causes those environment parameters to be "invisible" at runtime, for my system? If I deployed that same app on another machine, it would have been able to figure out the HOME string, right?[/quote]
Yes, so it is.
Instead of "Clear system Environment" you could just override it and reset or adjust the settings of some of the variables. Or just set the HOME variable to its original value (usually /Users/username on the Mac, with username being the short name, not the full name).