@Mike_Blackman said:

My application fails to load libqxcb.so plugin, because libqxcb.so plugin fails to locate Qt libraries. Prebuilt Qt solves this problem by using relative RUNPATH value within libqxcb.so.

Sorry, I don't know what the prebuilt libraries did to the RPATH/RUNPATH. You can ask the Qt engineers in the Interest mailing list: http://lists.qt-project.org/mailman/listinfo/interest (Subscribe to the list first, then post there)