Hi everyone! I'm found the solution of my problem with cross compilation on OS X. The solution is MXE. Here is script to install: #install all need tools using home brew. brew install autoconf automake coreutils gdk-pixbuf gettext gnu-sed gnu-tar intltool libtool p7zip wget xz #install scons tool ruby -e "$(curl -fsSL https://raw.githubusercontent.com/Homebrew/install/master/install)" < /dev/null 2> /dev/null brew install scons mkdir mxe && cd mxe #install mxe git clone https://github.com/mxe/mxe.git . export PATH=$PATH:/usr/local/opt/gettext/bin #install qt 5 for windows 32 bit by default. make EXCLUDE_PKGS='gsoap' qt5 After install you will need to add compiler to QtCreator. Also add path to MXE bin folder: <path_to_mxe_foler>/usr/x86_64-apple-darwin16.1.0/bin <path_to_mxe_foler>/usr/bin Thats it! Now I test it on my project and let you now about results.