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I want to distribute the .so or .dll files. Is it normal that Qt5Guid.dll, Qt5Cored.dll and Qt5Widgetsd.dll together are 300MB. Is there a way to reduce it in order to provide a "light" software to the user?
Qt5Guid.dll, Qt5Cored.dll are Debug DLL's, so you normally don't distribute those!
For distribution you should make a Release version that uses Qt5Gui.dll, Qt5Core.dll and so on...
Release DLL's should be quite a bit smaller than Debug versions...