Can you suggest efficient way for many queries

Simply open the connection once and use it for your queries. Close the connection when the app is closed.

but it make my ui stuck to wait for release mutex lock

Well, then analyse and fix your code - you have a dead-lock

but this is the problem

No, it's not.
I already wrote before: Create one connection in each thread.

So what is other efficient solution to tackle this issue ?

Can you suggest efficient way for many queries

Simply open the connection once and use it for your queries. Close the connection when the app is closed.

i am opening database and closing database when i want to execute sqlite query

Quite inefficient if you execute many queries

then How to make it simultaneously access

Create one connection in each thread...

SQLite can be safely used by multiple threads provided that no single database connection is used simultaneously in two or more threads.

I want elaboration of this statement

" SQLite can be safely used by multiple threads provided that no single database connection is used simultaneously in two or more threads."

If meaning of this statement is " i can not use same database connection in multiple thread" then How to make it simultaneously access ?

Multi-thread. In this mode, SQLite can be safely used by multiple threads provided that no single database connection is used simultaneously in two or more threads.